2018 Volume 13 Issue 3
Article Contents

Wang Hongfang, Zhao Fei, Wang Wei, Ru Shaoguo. Effects of Endocrine Disrupting Chemicals on Pancreas Development and the Related Mechanisms[J]. Asian Journal of Ecotoxicology, 2018, 13(3): 9-18. doi: 10.7524/AJE.1673-5897.20180303001
Citation: Wang Hongfang, Zhao Fei, Wang Wei, Ru Shaoguo. Effects of Endocrine Disrupting Chemicals on Pancreas Development and the Related Mechanisms[J]. Asian Journal of Ecotoxicology, 2018, 13(3): 9-18. doi: 10.7524/AJE.1673-5897.20180303001

Effects of Endocrine Disrupting Chemicals on Pancreas Development and the Related Mechanisms

  • Received Date: 03/03/2018
    Fund Project:
  • Endocrine disrupting chemicals (EDCs) are released into the environment from different sources. Recent experimental studies on animal models have shown that multiple EDCs can disrupt the pancreas development in early life and increase the risk of metabolic diseases in adulthood. However, the underlying mechanisms are not fully understood. This study focused on reviewing the effects of EDCs on pancreas development of different animal models. These effects mainly include islet β cell structure damage and dysfunction, decreased islet size, islet malformation, delayed secondary islet formation, and shortened pancreas length, etc. Further, mechanisms underlying these effects were reviewed in aspects of transcription factors, oxidative stress, and epigenetic modifications. This review will provide reference for the health risk assessment of EDCs.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(1446) PDF downloads(14) Cited by(0)

Access History

Effects of Endocrine Disrupting Chemicals on Pancreas Development and the Related Mechanisms

Fund Project:

Abstract: Endocrine disrupting chemicals (EDCs) are released into the environment from different sources. Recent experimental studies on animal models have shown that multiple EDCs can disrupt the pancreas development in early life and increase the risk of metabolic diseases in adulthood. However, the underlying mechanisms are not fully understood. This study focused on reviewing the effects of EDCs on pancreas development of different animal models. These effects mainly include islet β cell structure damage and dysfunction, decreased islet size, islet malformation, delayed secondary islet formation, and shortened pancreas length, etc. Further, mechanisms underlying these effects were reviewed in aspects of transcription factors, oxidative stress, and epigenetic modifications. This review will provide reference for the health risk assessment of EDCs.

Reference (0)

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint