Turner A, Holmes L, Thompson R C, et al. Metals and marine microplastics:Adsorption from the environment versus addition during manufacture, exemplified with lead[J]. Water Research, 2020, 173:115577
Kazour M, Terki S, Rabhi K, et al. Sources of microplastics pollution in the marine environment:Importance of wastewater treatment plant and coastal landfill[J]. Marine Pollution Bulletin, 2019, 146:608-618
Lambert S, Wagner M.Characterisation of nanoplastics during the degradation of polystyrene[J]. Chemosphere, 2016, 145:265-268
钱亚茹, 石磊磊, 沈茜, 等. 淡水环境中微塑料污染及毒性效应研究进展[J]. 环境工程技术学报, 2022, 12(4):1096-1104 Qian Y R, Shi L L, Shen Q, et al. Research progress on pollution and toxic effects of microplastics in freshwater environment[J]. Journal of Environmental Engineering Technology, 2022, 12(4):1096-1104(in Chinese)
李娇, 陈大岭, 陈玉立, 等. 微纳米塑料的人体健康风险研究进展[J]. 生态毒理学报, 2023, 18(2):175-187 Li J, Chen D L, Chen Y L, et al. Effects of micro/nano plastics on human health:A review[J]. Asian Journal of Ecotoxicology, 2023, 18(2):175-187(in Chinese)
Alimba C G, Faggio C. Microplastics in the marine environment:Current trends in environmental pollution and mechanisms of toxicological profile[J]. Environmental Toxicology and Pharmacology, 2019, 68:61-74
Schwabl P, Köppel S, Königshofer P, et al. Detection of various microplastics in human stool:A prospective case series[J]. Annals of Internal Medicine, 2019, 171(7):453-457
Amereh F, Amjadi N, Mohseni-Bandpei A, et al. Placental plastics in young women from general population correlate with reduced foetal growth in IUGR pregnancies[J]. Environmental Pollution, 2022, 314:120174
Leslie H A, van Velzen M J M, Brandsma S H, et al. Discovery and quantification of plastic particle pollution in human blood[J]. Environment International, 2022, 163:107199
刘雅宣, 王兰, 师庆英, 等. 微塑料的人体暴露和健康风险研究进展[J]. 生态毒理学报, 2022, 17(3):354-365 Liu Y X, Wang L, Shi Q Y, et al. Research progress on human exposure and health risks of microplastics[J]. Asian Journal of Ecotoxicology, 2022, 17(3):354-365(in Chinese)
Vethaak A D, Legler J. Microplastics and human health[J]. Science, 2021, 371(6530):672-674
Tong X H, Li B Q, Li J, et al. Polyethylene microplastics cooperate with Helicobacter pylori to promote gastric injury and inflammation in mice[J]. Chemosphere, 2022, 288(Pt 2):132579
Luo T, Wang C Y, Pan Z H, et al. Maternal polystyrene microplastic exposure during gestation and lactation altered metabolic homeostasis in the dams and their F1 and F2 offspring[J]. Environmental Science & Technology, 2019, 53(18):10978-10992
Wang L X, Wang Y X, Xu M, et al. Enhanced hepatic cytotoxicity of chemically transformed polystyrene microplastics by simulated gastric fluid[J]. Journal of Hazardous Materials, 2021, 410:124536
Yee M S L, Hii L W, Looi C K, et al. Impact of microplastics and nanoplastics on human health[J]. Nanomaterials, 2021, 11(2):496
Hesler M, Aengenheister L, Ellinger B, et al. Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro[J]. Toxicology in Vitro:An International Journal Published in Association with BIBRA, 2019, 61:104610
Cortés C, Domenech J, Salazar M, et al. Nanoplastics as a potential environmental health factor:Effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells[J]. Environmental Science:Nano, 2020, 7(1):272-285
Dong X S, Liu X B, Hou Q L, et al. From natural environment to animal tissues:A review of microplastics(nanoplastics) translocation and hazards studies[J]. The Science of the Total Environment, 2023, 855:158686
Campanale C, Massarelli C, Savino I, et al. A detailed review study on potential effects of microplastics and additives of concern on human health[J]. International Journal of Environmental Research and Public Health, 2020, 17(4):1212
Barboza L G A, Dick Vethaak A, Lavorante B R B O, et al. Marine microplastic debris:An emerging issue for food security, food safety and human health[J]. Marine Pollution Bulletin, 2018, 133:336-348
Bouwmeester H, Hollman P C H, Peters R J B. Potential health impact of environmentally released micro- and nanoplastics in the human food production chain:Experiences from nanotoxicology[J]. Environmental Science & Technology, 2015, 49(15):8932-8947
Domenech J, Hernández A, Rubio L, et al. Interactions of polystyrene nanoplastics with in vitro models of the human intestinal barrier[J]. Archives of Toxicology, 2020, 94(9):2997-3012
Hussain N, Jaitley V, Florence A T. Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics[J]. Advanced Drug Delivery Reviews, 2001, 50(1-2):107-142
Eldridge J H, Meulbroek J A, Staas J K, et al. Vaccine-containing biodegradable microspheres specifically enter the gut-associated lymphoid tissue following oral administration and induce a disseminated mucosal immune response[J]. Advances in Experimental Medicine and Biology, 1989, 251:191-202
Jani P U, McCarthy D E, Florence A T. Nanosphere and microsphere uptake via Peyer's patches:Observation of the rate of uptake in the rat after a single oral dose[J]. International Journal of Pharmaceutics, 1992, 86(2-3):239-246
Volkheimer G. Hematogenous dissemination of ingested polyvinyl chloride particles[J]. Annals of the New York Academy of Sciences, 1975, 246:164-171
Banerjee A, Shelver W L. Micro- and nanoplastic induced cellular toxicity in mammals:A review[J]. Science of the Total Environment, 2021, 755:142518
Varela J A, Bexiga M G, Åberg C, et al. Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells[J]. Journal of Nanobiotechnology, 2012, 10:39
Nowak M, Brown T D, Graham A, et al. Size, shape, and flexibility influence nanoparticle transport across brain endothelium under flow[J]. Bioengineering & Translational Medicine, 2020, 5(2):e10153
Firdessa R, Oelschlaeger T A, Moll H. Identification of multiple cellular uptake pathways of polystyrene nanoparticles and factors affecting the uptake:Relevance for drug delivery systems[J]. European Journal of Cell Biology, 2014, 93(8-9):323-337
Gratton S E, Ropp P A, Pohlhaus P D, et al. The effect of particle design on cellular internalization pathways[J]. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(33):11613-11618
Carr K E, Smyth S H, McCullough M T, et al. Morphological aspects of interactions between microparticles and mammalian cells:Intestinal uptake and onward movement[J]. Progress in Histochemistry and Cytochemistry, 2012, 46(4):185-252
Schmidt C, Lautenschlaeger C, Collnot E M, et al. Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa:A first in vivo study in human patients[J]. Journal of Controlled Release:Official Journal of the Controlled Release Society, 2013, 165(2):139-145
Li S, Malmstadt N. Deformation and poration of lipid bilayer membranes by cationic nanoparticles[J]. Soft Matter, 2013, 9(20):4969-4976
Xie W, You J, Zhi C X, et al. The toxicity of ambient fine particulate matter (PM2.5) to vascular endothelial cells[J]. Journal of Applied Toxicology, 2021, 41(5):713-723
Gopinath P M, Saranya V, Vijayakumar S, et al. Assessment on interactive prospectives of nanoplastics with plasma proteins and the toxicological impacts of virgin, coronated and environmentally released-nanoplastics[J]. Scientific Reports, 2019, 9:8860
Hollóczki O, Gehrke S. Nanoplastics can change the secondary structure of proteins[J]. Scientific Reports, 2019, 9:16013
Goodman K E, Hare J T, Khamis Z I, et al. Exposure of human lung cells to polystyrene microplastics significantly retards cell proliferation and triggers morphological changes[J]. Chemical Research in Toxicology, 2021, 34(4):1069-1081
Xu M K, Halimu G, Zhang Q R, et al. Internalization and toxicity:A preliminary study of effects of nanoplastic particles on human lung epithelial cell[J]. The Science of the Total Environment, 2019, 694:133794
Cheng W, Li X L, Zhou Y, et al. Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids[J]. The Science of the Total Environment, 2022, 806(Pt 1):150328
Hirt N, Body-Malapel M. Immunotoxicity and intestinal effects of nano- and microplastics:A review of the literature[J]. Particle and Fibre Toxicology, 2020, 17(1):57
Muittari A, Veneskoski T. Natural and synthetic fibers as causes of asthma and rhinitis[J]. Annals of Allergy, 1978, 41(1):48-50
Pimentel J C, Avila R, Lourenço A G. Respiratory disease caused by synthetic fibres:A new occupational disease[J]. Thorax, 1975, 30(2):204-219
Li B Q, Ding Y F, Cheng X, et al. Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice[J]. Chemosphere, 2020, 244:125492
Liu S, Li H, Wang J, et al. Polystyrene microplastics aggravate inflammatory damage in mice with intestinal immune imbalance[J]. Science of the Total Environment, 2022, 833:155198
Deng Y F, Yan Z H, Shen R Q, et al. Microplastics release phthalate esters and cause aggravated adverse effects in the mouse gut[J]. Environment International, 2020, 143:105916
Shi C Z, Han X H, Guo W, et al. Disturbedgut-liver axis indicating oral exposure to polystyrene microplastic potentially increases the risk of insulin resistance[J]. Environment International, 2022, 164:107273
Jin Y X, Lu L, Tu W Q, et al. Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice[J]. The Science of the Total Environment, 2019, 649:308-317
Hwang J, Choi D, Han S, et al. An assessment of the toxicity of polypropylene microplastics in human derived cells[J]. Science of the Total Environment, 2019, 684:657-669
Ding Y F, Zhang R Q, Li B Q, et al. Tissue distribution of polystyrene nanoplastics in mice and their entry, transport, and cytotoxicity to GES-1 cells[J]. Environmental Pollution, 2021, 280:116974
Domenech J, de Britto M, Velázquez A, et al. Long-term effects of polystyrene nanoplastics in human intestinal caco-2 cells[J]. Biomolecules, 2021, 11(10):1442
Eleutherio E C A, Silva Magalhães R S, de Araújo Brasil A, et al. SOD1, more than just an antioxidant[J]. Archives of Biochemistry and Biophysics, 2021, 697:108701
Johnson P. Antioxidant enzyme expression in health and disease:Effects of exercise and hypertension[J]. Comparative Biochemistry and Physiology Toxicology & Pharmacology, 2002, 133(4):493-505
Jakubczyk K, Dec K, Kałduńska J, et al. Reactive oxygen species-sources, functions, oxidative damage[J]. Polski Merkuriusz Lekarski:Organ Polskiego Towarzystwa Lekarskiego, 2020, 48(284):124-127
Wang X, Zheng H, Zhao J, et al. Photodegradation elevated the toxicity of polystyrene microplastics to grouper (Epinephelus moara) through disrupting hepatic lipid homeostasis[J]. Environmental Science & Technology, 2020, 54(10):6202-6212
DeLoid G M, Cao X Q, Bitounis D, et al. Toxicity, uptake, and nuclear translocation of ingested micro-nanoplastics in an in vitro model of the small intestinal epithelium[J]. Food and Chemical Toxicology:An International Journal Published for the British Industrial Biological Research Association, 2021, 158:112609
Bhagat J, Ingole B S. Glutathione S-transferase, catalase, superoxide dismutase, glutathione peroxidase, and lipid peroxidation as a biomarkers of oxidative stress in snails:A review[D]. Modena:University of Modena and Reggio Emilia, 2016:336-349
He Y J, Li Z, Xu T, et al. Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway[J]. Chemosphere, 2022, 307(Pt 1):135662
Deng Y F, Zhang Y, Lemos B, et al. Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure[J]. Scientific Reports, 2017, 7:46687
Rubio L, Marcos R, Hernández A. Potential adverse health effects of ingested micro- and nanoplastics on humans. Lessons learned from in vivo and in vitro mammalian models[J]. Journal of Toxicology and Environmental Health Part B, Critical Reviews, 2020, 23(2):51-68
Powell J J, Thoree V, Pele L C. Dietary microparticles and their impact on tolerance and immune responsiveness of the gastrointestinal tract[J]. The British Journal of Nutrition, 2007, 98(Suppl 1):S59-S63
Huang D J, Zhang Y, Long J L, et al. Polystyrene microplastic exposure induces insulin resistance in mice via dysbacteriosis and pro-inflammation[J]. The Science of the Total Environment, 2022, 838(Pt 1):155937
Cortés C, Domenech J, Salazar M, et al. Nanoplastics as a potential environmental health factor:Effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells[J]. Environmental Science:Nano, 2020, 7(1):272-285
Forte M, Iachetta G, Tussellino M, et al. Polystyrene nanoparticles internalization in human gastric adenocarcinoma cells[J]. Toxicology in Vitro, 2016, 31:126-136
Reuter S, Gupta S C, Chaturvedi M M, et al. Oxidative stress, inflammation, and cancer:How are they linked?[J]. Free Radical Biology and Medicine, 2010, 49(11):1603-1616
Yan X M, Zhang Y Y, Lu Y Q, et al. The complex toxicity of tetracycline with polystyrene spheres on gastric cancer cells[J]. International Journal of Environmental Research and Public Health, 2020, 17(8):2808
Chen Z X, Wang C Y, Yu N Z, et al. INF2 regulates oxidative stress-induced apoptosis in epidermal HaCaT cells by modulating the HIF1 signaling pathway[J]. Biomedecine & Pharmacotherapie, 2019, 111:151-161
Qiao J Y, Chen R, Wang M J, et al. Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction[J]. Nanoscale, 2021, 13(19):8806-8816
Lu L, Wan Z Q, Luo T, et al. Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice[J]. The Science of the Total Environment, 2018, 631-632:449-458
Zhao L T, Shi W Y, Hu F F, et al. Prolonged oral ingestion of microplastics induced inflammation in the liver tissues of C57BL/6J mice through polarization of macrophages and increased infiltration of natural killer cells[J]. Ecotoxicology and Environmental Safety, 2021, 227:112882
Wan Z Q, Wang C Y, Zhou J J, et al. Effects of polystyrene microplastics on the composition of the microbiome and metabolism in larval zebrafish[J]. Chemosphere, 2019, 217:646-658
Zhao Y, Bao Z W, Wan Z Q, et al. Polystyrene microplastic exposure disturbs hepatic glycolipid metabolism at the physiological, biochemical, and transcriptomic levels in adult zebrafish[J]. Science of the Total Environment, 2020, 710:136279
Shi L, Tu B P. Acetyl-CoA and the regulation of metabolism:Mechanisms and consequences[J]. Current Opinion in Cell Biology, 2015, 33:125-131
Zhou P, Santoro A, Peroni O D, et al. PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms[J]. The Journal of Clinical Investigation, 2019, 129(10):4138-4150
Syed I, Lee J, Moraes-Vieira P M, et al. Palmitic acid hydroxystearic acids activate GPR40, which is involved in their beneficial effects on glucose homeostasis[J]. Cell Metabolism, 2018, 27(2):419-427.e4
Vijayakumar A, Aryal P, Wen J, et al. Absence of carbohydrate response element binding protein in adipocytes causes systemic insulin resistance and impairs glucose transport[J]. Cell Reports, 2017, 21(4):1021-1035
Wen B, Zhang N, Jin S R, et al. Microplastics have a more profound impact than elevated temperatures on the predatory performance, digestion and energy metabolism of an Amazonian cichlid[J]. Aquatic Toxicology, 2018, 195:67-76
Schlein C, Talukdar S, Heine M, et al. FGF21 lowers plasma triglycerides by accelerating lipoprotein catabolism in white and brown adipose tissues[J]. Cell Metabolism, 2016, 23(3):441-453
Iizuka K, Takeda J, Horikawa Y. Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes[J]. FEBS Letters, 2009, 583(17):2882-2886
Bi Y K, Chang Y, Liu Q, et al. ERp44/CG9911 promotes fat storage in Drosophila adipocytes by regulating ER Ca2+homeostasis[J]. Aging, 2021, 13(11):15013-15031
Simha V, Garg A. Lipodystrophy:Lessons in lipid and energy metabolism[J]. Current Opinion in Lipidology, 2006, 17(2):162-169
Iizuka K, Ken T K, Yabe D. ChREBP-mediated regulation of lipid metabolism:Involvement of the gut microbiota, liver, and adipose tissue[J]. Frontiers in Endocrinology, 2020, 11:587189
Nunes-Nesi A, Araújo W L, Obata T, et al. Regulation of the mitochondrial tricarboxylic acid cycle[J]. Current Opinion in Plant Biology, 2013, 16(3):335-343
Bougarne N, Weyers B, Desmet S J, et al. Molecular actions of PPARα in lipid metabolism and inflammation[J]. Endocrine Reviews, 2018, 39(5):760-802
Wang Q, Wu Y L, Zhang W J, et al. Lipidomics and transcriptomics insight into impacts of microplastics exposure on hepatic lipid metabolism in mice[J]. Chemosphere, 2022, 308(Pt 3):136591
Fan X P, Wei X J, Hu H L, et al. Effects of oral administration of polystyrene nanoplastics on plasma glucose metabolism in mice[J]. Chemosphere, 2022, 288(Pt 3):132607
Islinger M, Cardoso M J R, Schrader M. Be different-The diversity of peroxisomes in the animal kingdom[J]. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2010, 1803(8):881-897
Marion-Letellier R, Savoye G, Ghosh S. Fatty acids, eicosanoids and PPAR gamma[J]. European Journal of Pharmacology, 2016, 785:44-49
Bhatt-Wessel B, Jordan T W, Miller J H, et al. Role of DGAT enzymes in triacylglycerol metabolism[J]. Archives of Biochemistry and Biophysics, 2018, 655:1-11
Stone S J, Myers H M, Watkins S M, et al. Lipopenia and skin barrier abnormalities in DGAT2-deficient mice[J]. The Journal of Biological Chemistry, 2004, 279(12):11767-11776
Stock V, Fahrenson C, Thuenemann A, et al. Impact of artificial digestion on the sizes and shapes of microplastic particles[J]. Food and Chemical Toxicology, 2020, 135:111010
Strandwitz P. Neurotransmitter modulation by the gut microbiota[J]. Brain Research, 2018, 1693(Pt B):128-133