卤代有机污染物抑制甲状腺激素代谢酶活性的研究进展
Inhibition of Metabolic Activities of Thyroid Hormones by Halogenated Organic Contaminants
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摘要: 甲状腺激素(thyroid hormones, THs)对生物体细胞的正常发育和分化至关重要,甲状腺激素失调可引起中枢神经系统、肺、心血管和其他器官的异常发育。研究表明,环境中的卤代有机污染物(halogenated organic contaminants, HOCs)及其代谢产物具有甲状腺激素干扰效应。抑制参与THs代谢的生物酶,例如磺基转移酶(sulfotransferases, SULTs)和脱碘酶(deiodinases, DIs),是HOCs及其代谢产物干扰THs正常功能的重要方式。本文重点综述了HOCs对不同甲状腺激素代谢酶的抑制效应的研究,讨论了环境计算化学和预测毒理学方法在该领域的重要应用,期望为HOCs干扰甲状腺激素酶代谢活性的深入研究提供借鉴与参考。
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关键词:
- 卤代有机污染物(HOCs) /
- 甲状腺激素(THs) /
- 磺基转移酶(SULTs) /
- 脱碘酶(DIs) /
- 磺酸化 /
- 脱碘
Abstract: Thyroid hormones (THs) are essential for the normal development and differentiation of all cells in the organisms. Thyroid hormones disorder can cause abnormal development of the central nervous system, lungs, cardiovascules and other organs. It has been reported that the halogenated organic contaminants (HOCs) in the environment and their metabolites have thyroid-disrupting effects. Inhibiting the activity of biological enzymes involved in the metabolism of THs, such as sulfotransferases (SULTs) and deiodinases (DIs), is an important way for HOCs and their metabolites to interfere with the normal functions of THs. Here, we mainly reviewed the inhibition effects of HOCs on the TH enzymes, and discussed the application of environmental computational chemistry and predictive toxicology methods in this field. It is expected to provide reference for the further research on HOCs interfering with the metabolic activities of thyroid hormone enzymes. -
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