摘要:
持久性有机污染物(persistent organic pollutants，简称POPs)大多具有毒性，有的甚至致癌，但目前对POPs引起的健康风险仍知之甚少。本研究的假设是在含POPs场地邮政区居住妇女的乳腺癌风险增大。从纽约州计划与研究合作系统(SPARCS)等数据库中收集乳腺癌患者的信息及居住地危险废弃物暴露、经济收入和城市化等数据。以邮政区编码表征居住地，采用负二项回归方法，对纽约州30岁以上妇女乳腺癌医院出院率进行了模型分析，参数包括种族、年龄、污染暴露、经济收入和城市化率。结果显示，不同参数之间(如暴露与种族、暴露与收入、暴露与城市化)存在交互作用。对部分子群而言，与居住在不含危险废弃物场地邮政区的妇女相比，居住在含POPs场地邮政区的妇女乳腺癌出院率显著升高(率比(rate ratio,RR)1.10~1.34，P<0.05)。这种关系在非裔妇女中强于白种妇女、在城市化高的地区强于农村地区。调整了混杂因素后，某些妇女人群乳腺癌出院率升高与在含POPs场地邮政区居住有显著的关系。
Abstract:
Persistent organic pollutants (in abbreviation, POPs) are mostly toxic, with some even carcinogenic; however, currently the health risks caused by POPs are still poorly understood. The hypothesis of this research is that residence in zip code containing POPs site increases the risk of female breast cancer. The information of breast cancer patients as well as data of waste exposure, economic income and urbanization of residence areas were collected from databases including the New York Statewide Planning and Research Cooperative System (SPARCS), etc. The Zip Code was used to characterize the residence area. Negative binomial regression was applied to model the hospital discharge rate of breast cancer for women over 30 years old and the description parameters included exposure, age, ethnicity, income and urbanization. The results showed that there were interactions between the parameters (such as exposure and ethnicity, exposure and income, exposure and urbanization). For some subgroups, as compared to women living in zip code without hazardous waste sites, women living in zip code containing POPs sites had significantly increased discharge rates of breast cancer (rate ratio (RR) 1.10 - 1.34, P<0.05). This relationship was stronger in African American than Caucasian women and stronger in more urbanized areas than in rural areas. After adjustment for the confounders, the hospital discharge rate of breast cancer was significantly associated with residence in zip code containing POPs sites for some women.
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