Keywords: 
• progestogens /
• glucocorticoids /
• environmental behavior /
• ecotoxicology /
• endocrine disruption /
• circadian rhythm /
• immune response

Abstract: Environmental behavior and ecotoxicological effects of progestogens and glucocorticoids are of increasing concern in recent years. They are used in a range of medical conditions, and reach aquatic ecosystem due to the incomplete removal by wastewater treatment plant (WWTP) and agricultural run-off, then cause the potential hazard to the ecological system and human health. A few ng·L^-1 of progestogens and glucocorticoids were widely detected in surface water while in the influents and effluents of WWTP the concentrations were up to several hundred ng·L^-1. They exert toxic effects primarily via binding to nuclear hormone receptors, for instance, the progesterone receptor (PR), glucocorticoid receptor (GR) and mineralocorticoid receptor (MR). Endocrine disrupts of aquatic vertebrates are of mainly concern. They alter the transcriptional levels of genes involved in hypothalamic-pituitary-gonadal axis and blood hormone concentrations, impact gonadal histology and disrupt fish reproduction, even at environmental relevant levels. Besides, novel targets are uncovered recently by use of "Omics" technology, such as the alterations on circadian rhythm signals and immune responses. These provide us novel insights of potential ecotoxicological effects of progestogens and glucocorticoids.