氧化石墨烯抗菌性及生物安全性研究进展
Progress on Antibacterial and Biosafety Research of Graphene Oxide
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摘要:
氧化石墨烯是一种表面有丰富含氧官能团的石墨烯衍生物，具有与石墨烯相似的二维蜂窝状晶格结构，从而导致了其具有电学、光学、力学特性和良好的生物相容性，被广泛应用于材料学、生物医学和药物传递等诸多领域。因氧化石墨烯日益增多的生产和使用，其在空气、水和土壤中大量积累，引发了人们对其生物安全性的高度关注。以微生物、陆生动植物和水生动植物为分类标准，综述了近几年氧化石墨烯对微生物、动物和植物的毒性影响，总结并分析了三者的毒性机理，比较了不同生存环境下其对动植物毒性影响的不同，旨在更加全面地揭示氧化石墨烯的生物安全性，为氧化石墨烯安全使用剂量和其功能化应用提供一定的参考。
Abstract:Graphene oxide is a graphene derivative with abundant oxygen-containing functional groups on its surface. It has a two-dimensional honeycomb lattice structure similar to that of graphene, which leads to its electrical, optical, and mechanical properties and a good biocompatibility. Graphene oxide has been widely used in many fields, such as materials science, biomedicine, and drug delivery. Due to the increasing production and usage of graphene oxide products, this chemical is substantially accumulated in air, water, and soil, which undoubtedly increases the possibility of direct human contact. Therefore, the biosafety of graphene oxide has been brought to the public’s attention. By using microorganisms, terrestrial organisms, and aquatic organisms as three main categories, this paper reviewed recent studies about the toxic effects of graphene oxide on those organisms and summarized the mechanisms of the respective toxicities. Further, we compared the effects of different living environments on the toxicity to plants and animals. This paper, hopefully, can reveal the biosafety of graphene oxide more comprehensively and provide a reference to the safe dosage and functional application of graphene oxide.
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Key words:
- graphene oxide /
- antibacterial /
- biological safety
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