雌激素受体作为壬基酚的主要作用靶点导致机体免疫毒性
The Role of Estrogen Receptor as Main Target in the Immunotoxicity Induced by Nonylphenol
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摘要: 雌激素作为一类重要的性腺类固醇化学信使，已经被证实能够直接调节机体免疫反应，因此，一些具有拟雌激素特性的环境内分泌干扰物(endocrine disruptors, EDs)，会通过影响雌激素相关信号通路对免疫系统产生干扰作用。壬基酚(nonylphenol, NP)作为典型的环境内分泌干扰物，已有大量的文献报道其通过拟雌激素特性或干扰雌激素的合成、分泌、转运以及与靶点的结合，破坏机体生殖功能以及神经-免疫-内分泌系统，影响整体生理平衡与稳定。近年来，NP对免疫系统的干扰作用逐渐引起重视，研究发现，NP暴露会引起小鼠免疫器官及免疫细胞的发育异常，并且会导致新生小鼠肝毒性，肝脏细胞内炎性因子TNF-α、IL-1β分泌增加。除NP作为配体干扰雌激素信号通路外，尚未发现其他明确的分子机制解释NP造成的免疫毒性。本综述主要结合近年来相关的实验结果，总结了NP对免疫系统的潜在影响及其可能的分子机制。Abstract: Estrogen acts as a chemical messenger in target tissues regulating immune responses, and therefore estrogen-like endocrine disrupting chemical can act on estrogen-mediated signal transduction pathway and induce damage to immune system. Nonylphenol (NP), an endocrine disrupting chemical with estrogen-like effects, can interfere with the synthesis, secretion and transport of estrogen, and disrupt reproductive and neural-immunity-endocrine systems as well as physiological balance and stability in body. Previous studies revealed that NP exposure could cause the developmental disorders of immune organs and cells, which further could lead to hepatotoxicity that involved an increase in the secretion of TNF-α and IL-1β in mice. The mechanism is associated with the disruption of estrogen signaling pathway induced by NP. We summarize the key findings from the recent scientific literature, identify the potential effects of NP on immune system and its molecular mechanisms.
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Key words:
- nonylphenol /
- immunotoxicity /
- estrogens /
- estrogen receptor
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