垃圾渗滤液中典型内分泌干扰物质(EDCs)细胞毒性分析
Cytotoxicity Analysis of Typical Endocrine Disrupting Chemicals (EDCs) in Landfill Leachate
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摘要: 垃圾渗滤液的人类健康风险评估日益受到人们重视,也成为研究热点。本文采用一种新型高级氧化技术UV-Fenton处理渗滤液,并用人体乳腺癌细胞(MCF-7)评估处理过程中渗滤液原液以及渗滤液中典型内分泌干扰物质(EDCs)的细胞毒性,对垃圾渗滤液中EDCs的细胞毒性和变化规律进行了研究。结果表明渗滤液中的邻苯二甲酸二丁酯(DBP)、双酚A(BPA)、壬基酚(NP)是产生细胞毒性的主要物质,其毒性大小为DBP>BPA>NP。在同样的氧化降解过程中显示出不同毒性变化规律,通过GC-MS分析,结果显示UV-Fenton过程中产生了大量的中间产物,这也是引起毒性变化的主要原因。实验结果也说明垃圾渗滤液细胞毒性可以通过UV-Fenton过程有效去除。Abstract: Recently, the health risk assessment on the landfill leachate has attracted increasing attentions and has become a research focus. In the present study, a novel advanced oxidation technology (UV-Fenton technology) was adopted to treat the leachate, and the cell toxicity of raw leachate and typical EDCs in the leachate in the treatment process has been evaluated by using human breast cancer cells (MCF-7). The results indicated that di-butyl phthalate (DBP), bisphenol A (BPA) and nonylphenol (NP) in the leachate were main substances which have significant cytotoxicity on MCF-7 cells. The toxicity variations of these three chemicals were different in the same oxidative degradation process, and the toxicity order was DBP > BPA > NP. According to the GC-MS analysis results, a great amount of intermediate products have been produced in UV-Fenton process, which may be a major reason that induced toxicity variations. The results implied that UV-Fenton technology is an effective method to reduce toxicity of landfill leachate.
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