4种甲氧基丙烯酸酯类杀菌剂不同剂型对斑马鱼急性毒性效应
Acute Toxicity of Different Formulation of Four Strobilurin Fungicides to the Zebrafish (Brachydonio rerio)
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摘要: 采用半静态法测定了4种甲氧基丙烯酸酯类杀菌剂原药及制剂对斑马鱼(Brachydonio rerio)急性毒性。结果表明,以实测浓度计,250 g·L-1嘧菌酯悬浮剂对斑马鱼的96 h半数致死浓度(LC50)值为0.539 mg·L-1,急性毒性为高毒,95%嘧菌酯原药和50%嘧菌酯水分散粒剂对斑马鱼的LC50(96 h)值分别为1.09和1.21 mg·L-1,急性毒性均为中毒;98%啶氧菌酯原药和22.5%的啶氧菌酯悬浮剂对斑马鱼的LC50(96 h)值分别为0.0974和0.0972 mg·L-1,急性毒性均为剧毒;95%吡唑醚菌酯原药、15%吡唑醚菌酯悬浮剂和250 g·L-1吡唑醚菌酯乳油对斑马鱼的LC50(96 h)值为0.0613、0.0549和0.0487 mg·L-1,急性毒性均为剧毒;95%醚菌酯原药和50%醚菌酯水分散粒剂对斑马鱼的LC50(96 h)值分别为0.468和0.702 mg·L-1,急性毒性均为高毒。这4种甲氧基丙烯酸酯类杀菌剂对斑马鱼均有较高风险,会对其他水生生物也存在潜在的风险。
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关键词:
- 甲氧基丙烯酸酯类杀菌剂 /
- 斑马鱼 /
- 急性毒性 /
- 剂型 /
- 中毒症状
Abstract: Acute toxicity of different formulation of four strobilurin fungicides to zebrafish (Brachydonio rerio) was detected with the semi-static method. Based on measured concentrations, results showed that 250 g·L-1 azoxystrobin suspension concentrate (SC) is very toxic to zebrafish with an LC50 (96 h) value of 0.539 mg·L-1. In contrast, 95% azoxystrobin technical material (TC) and 50% azoxystrobin water dispersible granule (WG) were moderately toxic to zebrafish with LC50 (96 h) values of 1.09 and 1.21 mg·L-1, respectively. Both 98% picoxystrobin TC and 22.5% picoxystrobin SC were extremely toxic to zebrafish with LC50 (96 h) values of 0.0974 and 0.0972 mg·L-1. All test fungicides pyraclostrobin were also extremely toxic to zebrafish with the relative toxicity (LC50) in decreasing order as follows: 95% pyraclostrobin TC (0.0613 mg·L-1)> 15% pyraclostrobin SC (0.0549 mg·L-1)>250 g·L-1 pyraclostrobin emulsifiable concentrates (EC) (0.0487 mg·L-1). 95% kresoxim-methyl TC and 50% kresoxim-methyl WG were very toxic to zebrafish, and their LC50 (96 h) values were 0.468 and 0.702 mg·L-1, respectively. These results suggested that all tested strobilurin fungicides have the potential risk to zebrafish and the other aquatic organisms.-
Key words:
- strobilurin fungicides /
- zebrafish /
- acute toxicity /
- pesticide formation /
- toxic symptom
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