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徐红梅,宣怡红,江云,任娜,等. 溴化1-十四烷基-3-甲基咪唑对小鼠的肝脏毒性及其作用机制[J]. 生态毒理学报, 2013, 8(5): 791-798
溴化1-十四烷基-3-甲基咪唑对小鼠的肝脏毒性及其作用机制
The Hepatotoxicity and Mechanism of Bromide 1-Tetradecyl-3-Methyl Imidazole to Mice
投稿时间:2013-05-08  修订日期:2013-07-10
DOI:10.7524/AJE.1673-5897.20130508001
中文关键词:  离子液体  溴化1-十四烷基-3-甲基咪唑盐  肝毒性  小鼠
英文关键词:ionic liquids  bromide 1-tetradecyl-3-methyl imidazole salt  hepatotoxicity  KM mouse
基金项目:国家自然科学基金(50973025);合肥工业大学大学生创新创业实验(2012CXCY475)
作者单位
徐红梅 1. 合肥工业大学医学工程学院 制药工程系合肥 230009 2. 合肥工业大学安徽省先进功能材料与设备重点实验室合肥 230009 
宣怡红 合肥工业大学医学工程学院 制药工程系合肥 230009 
江云 合肥工业大学医学工程学院 制药工程系合肥 230009 
任娜 合肥工业大学化学工程学院合肥 23000 
丁运生 1. 合肥工业大学安徽省先进功能材料与设备重点实验室合肥 230009 2. 合肥工业大学化学工程学院合肥 23000 
吕丹 合肥工业大学医学工程学院 制药工程系合肥 230009 
张毅帆 合肥工业大学医学工程学院 制药工程系合肥 230009 
李小雪 合肥工业大学医学工程学院 制药工程系合肥 230009 
周剑 合肥工业大学医学工程学院 制药工程系合肥 230009 
许凯兵 合肥工业大学医学工程学院 制药工程系合肥 230009 
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中文摘要:
      研究离子液体溴化1-十四烷基-3-甲基咪唑盐([C14mim]Br)对小鼠的肝脏毒性及其作用机制。实验设立3个剂量的染毒组(1/16 LD50、1/8 LD50、1/4 LD50)和1个空白对照组,考察昆明种小鼠染毒14 d后,[C14mim]Br对小鼠血清生化指标、肝脏抗氧化酶活性及脂质过氧化产物的影响,并观察肝脏组织的病理变化。与对照组相比,小鼠染毒后,血清中ALT、AST、DBIL和γ-GT明显升高;肝组织受到不同程度的损伤,HSI增大,蛋白质含量降低。当染毒剂量为1/4 LD50时,肝脏中SOD活性和GSH-Px活性显著降低,MDA的含量则明显增加。实验结果表明,[C14mim]Br可损伤小鼠的肝脏功能,破坏机体的抗氧化防御系统,造成氧化损伤和脂质过氧化。
                             
AuthorAffiliation
Xu Hongmei1. Department of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China 2. Anhui Provincial Key Laboratory of Advanced Functional Materials and Devices, Hefei University of Technology, Hefei 230009, China
Xuan YihongDepartment of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China
Jiang YunDepartment of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China
Ren NaSchool of Chemical Engineering, Hefei University of Technology, Hefei 230009, China
Ding Yunsheng1. Anhui Provincial Key Laboratory of Advanced Functional Materials and Devices, Hefei University of Technology, Hefei 230009, China 2. School of Chemical Engineering, Hefei University of Technology, Hefei 230009, China
Lv DanDepartment of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China
Zhang YifanDepartment of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China
Li XiaoxueDepartment of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China
Zhou JianDepartment of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China
Xu KaibingDepartment of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China
英文摘要:
      In order to study the hepatotoxicity of ionic liquid bromide 1-tetradecyl-3-methyl imidazole salt ([C14mim]Br) to mice and its mechanism, three different dosage groups (1/16 LD50, 1/8 LD50 and 1/4 LD50) and one blank control group were set up. After KM mice were treated with [C14mim]Br solution by intragastric administration for 14 days, the effects of [C14mim]Br on serum biochemical index, histomorphology, antioxidant enzymes and lipid peroxidation in mice liver were observed. Compared with the control group, the levels of alanine aminotransferase, aspartate aminotransferase, direct bilirubin and γ-glutamyl transpeptidase in serum of treated mice were all increased obviously. At meanwhile, damaged liver tissue, higher hepatosomatic index and lower protein content were also observed in treated mice. At the 1/4 LD50 group, superoxide dismutase activity and glutathione peroxidase content decreased significantly, while the content of malondialdehyde increased obviously. It is indicated that [C14mim]Br could cause damage to liver function of mouse and destroy its antioxidant system, leading to oxidative damage and lipid peroxidation.
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