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刘晓晖,胡宏,李双月,邵静,等. 全氟辛烷磺酸神经发育毒性机制研究进展[J]. 生态毒理学报, 2013, 8(5): 643-649
全氟辛烷磺酸神经发育毒性机制研究进展
Research Progress on Mechanisms in the Developmental Neurotoxicity of PFOS
投稿时间:2013-04-07  修订日期:2013-05-08
DOI:10.7524/AJE.1673-5897.20130407001
中文关键词:  PFOS  神经发育毒性    神经递质  神经胶质细胞
英文关键词:PFOS  developmental neurotoxicity  calcium  neurotransmitters  neurogliocyte
基金项目:国家自然基金(81273031);大连医科大学引进人才科研启动基金(201069);大连理工大学工业生态与环境工程教育部重点实验室开放基金(KLIEEE-12-04)
作者单位
刘晓晖 大连医科大学公共卫生学院 劳动卫生与环境卫生教研室大连 116044 
胡宏 大连医科大学附属二院检验科大连 116027 
李双月 大连医科大学公共卫生学院 劳动卫生与环境卫生教研室大连 116044 
邵静 大连医科大学公共卫生学院 劳动卫生与环境卫生教研室大连 116044 
刘薇 大连理工大学环境学院 工业生态与环境工程教育部重点实验室大连 116024 
金一和 大连理工大学环境学院 工业生态与环境工程教育部重点实验室大连 116024 
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中文摘要:
      全氟辛烷磺酸(PFOS)是全氟化合物的终端降解产物,在生态环境中能够通过食物链进入生物组织并蓄积,对环境和生物存在潜在危害。动物实验研究发现,PFOS能够通过胎盘和血脑屏障,影响发育期神经系统,其持续性和严重性已引起国内外学者的广泛关注。本文通过对PFOS神经发育毒性效应及其主要机制研究进展进行综述,分析目前研究现状,并对未来PFOS神经发育毒性机制研究提出设想和展望。
                 
AuthorAffiliation
Liu XiaohuiDepartment of Environmental Health and Toxicology, School of Public Health, Dalian Medical University, Dalian 116044, China
Hu HongBiochemistry Lab, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China
Li ShuangyueDepartment of Environmental Health and Toxicology, School of Public Health, Dalian Medical University, Dalian 116044, China
Shao JingDepartment of Environmental Health and Toxicology, School of Public Health, Dalian Medical University, Dalian 116044, China
Liu WeiKey Laboratory of Industrial Ecology and Environmental Engineering of Ministry of Education, School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China
Jin YiheKey Laboratory of Industrial Ecology and Environmental Engineering of Ministry of Education, School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China
英文摘要:
      Perfluorooctane sulfonates (PFOS), the terminal degradation products of perfluorinated compounds, can bioaccumulate through food chains and is regarded as a potential threat to our living environment. Studies in animals have shown that PFOS passes through placental barrier and blood brain barrier, and induces toxic effects in central nervous system (CNS). In particular, PFOS induces developmental neurotoxicity, and its severity and persistency have been widely recognized. In this current article, we thoroughly reviewed the developmental neurotoxicity by in vivo and in vitro exposure to PFOS and its underlying mechanisms. Furthermore, we discussed present problems in this area and put forward suggestions on future research.
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