磺胺与金属氧化物纳米颗粒对发光菌的急性联合毒性及其机制初探

周虹; 王大力; 葛鸿铭; 林志芬; 李时银

doi:10.7524/AJE.1673-5897.20160526001

生态毒理学报

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周虹, 王大力, 葛鸿铭, 林志芬, 李时银. 磺胺与金属氧化物纳米颗粒对发光菌的急性联合毒性及其机制初探[J]. 生态毒理学报, 2016, 11(5): 65-70. doi: 10.7524/AJE.1673-5897.20160526001

引用本文:

Zhou Hong, Wang Dali, Ge Hongming, Lin Zhifen, Li Shiyin. Acute Joint Effects and Mechanisms of Binary Toxicity of Sulfonamides and Metal Oxide Nanoparticles to Vibrio fischeri[J]. Asian journal of ecotoxicology, 2016, 11(5): 65-70. doi: 10.7524/AJE.1673-5897.20160526001

Citation:

Zhou Hong, Wang Dali, Ge Hongming, Lin Zhifen, Li Shiyin. Acute Joint Effects and Mechanisms of Binary Toxicity of Sulfonamides and Metal Oxide Nanoparticles to Vibrio fischeri[J]. Asian journal of ecotoxicology, 2016, 11(5): 65-70. doi: 10.7524/AJE.1673-5897.20160526001

磺胺与金属氧化物纳米颗粒对发光菌的急性联合毒性及其机制初探

1. 南京师范大学环境学院, 南京 210046;
2. 同济大学环境科学与工程学院污染控制与资源化研究国家重点实验室, 上海 200092

作者简介: 周虹(1993-),女,硕士研究生,研究方向为生态毒理学,E-mail:zhouhongmay@126.com

通讯作者: 林志芬, E-mail: lzhifen@tongji.edu.cn ; 李时银, E-mail: lishiyin@njnu.edu.cn

基金项目:
同济大学污染控制与资源化研究国家重点实验室自主研究(重点)项目(PCRRY11003)；国家自然科学面上基金(21377096，21577105)；同济大学英才(攀登计划)(0400219287)
中图分类号: X171.5

Acute Joint Effects and Mechanisms of Binary Toxicity of Sulfonamides and Metal Oxide Nanoparticles to Vibrio fischeri

1. College of Environment, Nanjing Normal University, Nanjing 210046, China;
2. College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai 200092, China

Corresponding authors: Lin Zhifen, lzhifen@tongji.edu.cn ; Li Shiyin, lishiyin@njnu.edu.cn

Fund Project:

摘要: 磺胺与金属氧化物纳米颗粒同作为抗菌剂对环境与人体健康皆有危害。为探究其对细菌的毒性作用，测定了4种磺胺，包括磺胺氯哒嗪(SCP)、磺胺吡啶(SPY)、磺胺甲基异恶唑(SMZ)、磺胺嘧啶(SD)，与3种金属氧化物纳米颗粒，纳米ZnO(n-ZnO)、纳米CuO(n-CuO)、纳米Cr₂O₃(n-Cr₂O₃)对发光菌(Vibrio fischeri)的单一毒性及二元急性联合毒性。结果表明，SCP对V. fischeri的单一毒性明显大于其他3种磺胺；n-ZnO的单一毒性远大于n-CuO和n-Cr₂O₃；磺胺与金属氧化物纳米颗粒的二元急性联合毒性效应表现为拮抗、相加和协同，协同居多，说明金属氧化物纳米颗粒增加了磺胺的生物毒性，两者在环境中的共存带来了更大的环境生态风险。
- 磺胺 /
- 纳米颗粒 /
- Vibrio fischeri /
- 急性联合毒性
Abstract: The antibiotics and nanopartilces acting as antimicrobial agents may both have harmful effects on the environment and the human health. In order to explore the toxic effects of them against the bacteria, 4 sulfonamides (sulfachloropyridazine (SCP), sulfapyridine (SPY), sulfamethoxazole (SMZ) and sulfadiazine (SD) and 3 metal oxide nanoparticles (n-ZnO, n-CuO and n-Cr₂O₃) were investigated for their single toxicity and binary joint effects on Vibrio fischeri. The results showed that the single toxicity of SCP to V. fischeri was significantly greater than the other three sulfonamides; and n-ZnO showed significantly greater toxicity than n-CuO and n-Cr₂O₃. Three types of joint effects, i.e., antagonistic, additive and synergetic, were observed with the binary mixtures of sulfonamides and nanoparticles, among which the synergetic effect was the most frequently observed. It was suggested that the metal oxide nanoparticles can enhance the biological toxicity of sulfonamides, and the coexistence of them in the environment may bring about greater environmental risks.
- sulfonamides /
- nanoparticles /
- Vibrio fischeri /
- acute joint effects

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Citation:

磺胺与金属氧化物纳米颗粒对发光菌的急性联合毒性及其机制初探

通讯作者: 林志芬, E-mail: lzhifen@tongji.edu.cn ; 李时银, E-mail: lishiyin@njnu.edu.cn

作者简介: 周虹(1993-),女,硕士研究生,研究方向为生态毒理学,E-mail:zhouhongmay@126.com
1. 南京师范大学环境学院, 南京 210046;

2. 同济大学环境科学与工程学院污染控制与资源化研究国家重点实验室, 上海 200092

收稿日期: 2016-05-26

基金项目:

同济大学污染控制与资源化研究国家重点实验室自主研究(重点)项目(PCRRY11003)；国家自然科学面上基金(21377096，21577105)；同济大学英才(攀登计划)(0400219287)

关键词:

摘要: 磺胺与金属氧化物纳米颗粒同作为抗菌剂对环境与人体健康皆有危害。为探究其对细菌的毒性作用，测定了4种磺胺，包括磺胺氯哒嗪(SCP)、磺胺吡啶(SPY)、磺胺甲基异恶唑(SMZ)、磺胺嘧啶(SD)，与3种金属氧化物纳米颗粒，纳米ZnO(n-ZnO)、纳米CuO(n-CuO)、纳米Cr₂O₃(n-Cr₂O₃)对发光菌(Vibrio fischeri)的单一毒性及二元急性联合毒性。结果表明，SCP对V. fischeri的单一毒性明显大于其他3种磺胺；n-ZnO的单一毒性远大于n-CuO和n-Cr₂O₃；磺胺与金属氧化物纳米颗粒的二元急性联合毒性效应表现为拮抗、相加和协同，协同居多，说明金属氧化物纳米颗粒增加了磺胺的生物毒性，两者在环境中的共存带来了更大的环境生态风险。

English Abstract

Acute Joint Effects and Mechanisms of Binary Toxicity of Sulfonamides and Metal Oxide Nanoparticles to Vibrio fischeri

Corresponding author: Lin Zhifen, lzhifen@tongji.edu.cn ;

Corresponding authors: Li Shiyin, lishiyin@njnu.edu.cn

1. College of Environment, Nanjing Normal University, Nanjing 210046, China;
2. College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai 200092, China

Received Date: 2016-05-26

Fund Project:

Keywords:

Abstract: The antibiotics and nanopartilces acting as antimicrobial agents may both have harmful effects on the environment and the human health. In order to explore the toxic effects of them against the bacteria, 4 sulfonamides (sulfachloropyridazine (SCP), sulfapyridine (SPY), sulfamethoxazole (SMZ) and sulfadiazine (SD) and 3 metal oxide nanoparticles (n-ZnO, n-CuO and n-Cr₂O₃) were investigated for their single toxicity and binary joint effects on Vibrio fischeri. The results showed that the single toxicity of SCP to V. fischeri was significantly greater than the other three sulfonamides; and n-ZnO showed significantly greater toxicity than n-CuO and n-Cr₂O₃. Three types of joint effects, i.e., antagonistic, additive and synergetic, were observed with the binary mixtures of sulfonamides and nanoparticles, among which the synergetic effect was the most frequently observed. It was suggested that the metal oxide nanoparticles can enhance the biological toxicity of sulfonamides, and the coexistence of them in the environment may bring about greater environmental risks.

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磺胺与金属氧化物纳米颗粒对发光菌的急性联合毒性及其机制初探

作者简介: 周虹(1993-),女,硕士研究生,研究方向为生态毒理学,E-mail:zhouhongmay@126.com

通讯作者: 林志芬, E-mail: lzhifen@tongji.edu.cn ; 李时银, E-mail: lishiyin@njnu.edu.cn

Acute Joint Effects and Mechanisms of Binary Toxicity of Sulfonamides and Metal Oxide Nanoparticles to Vibrio fischeri

Corresponding authors: Lin Zhifen, lzhifen@tongji.edu.cn ; Li Shiyin, lishiyin@njnu.edu.cn

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磺胺与金属氧化物纳米颗粒对发光菌的急性联合毒性及其机制初探

通讯作者: 林志芬, E-mail: lzhifen@tongji.edu.cn ; 李时银, E-mail: lishiyin@njnu.edu.cn

作者简介: 周虹(1993-),女,硕士研究生,研究方向为生态毒理学,E-mail:zhouhongmay@126.com 1. 南京师范大学 环境学院, 南京 210046; 2. 同济大学环境科学与工程学院 污染控制与资源化研究国家重点实验室, 上海 200092

English Abstract

Acute Joint Effects and Mechanisms of Binary Toxicity of Sulfonamides and Metal Oxide Nanoparticles to Vibrio fischeri

Corresponding author: Lin Zhifen, lzhifen@tongji.edu.cn ;

Corresponding authors: Li Shiyin, lishiyin@njnu.edu.cn

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作者简介: 周虹(1993-),女,硕士研究生,研究方向为生态毒理学,E-mail:zhouhongmay@126.com
1. 南京师范大学环境学院, 南京 210046;

2. 同济大学环境科学与工程学院污染控制与资源化研究国家重点实验室, 上海 200092