摘要:
目前动脉粥样硬化在全世界以惊人的速度增长,成为21世纪公共健康的严重挑战。持久性有机污染物(persistent organic pollutants,POPs)具有生物富集性和持久性,可通过各种环境介质对人体健康产生危害。研究表明POPs能够改变基因表达,加速动脉粥样硬化的发生发展,因而POPs被认为是动脉粥样硬化的致病风险因素之一。MicroRNAs (miRNAs)是生物进化过程中高度保守的一组非编码小分子RNA,在转录后水平调节基因的表达。miRNAs的差异表达涉及一系列疾病的生理和病理过程。有证据显示,POPs能够引起生物体内miRNAs的表达紊乱,从而引起基因的差异表达。大量文献报道也显示miRNAs在动脉粥样硬化中起重要作用。因此,POPs可能通过miRNA的潜在调控从而导致动脉粥样硬化的发生发展。
Abstract:
The global incidence of atherosclerosis has increased at an alarming rate, being a serious challenge to public health in 21th century. Because of the properties of bio-accumulation and persistence, persistent organic pollutants (POPs) could do harm to human health through different kinds of environmental media. Studies have shown POPs are risk factors of atherosclerosis, because they could exacerbate the development of by altering gene expression patterns. MicroRNAs (miRNAs) are a group of highly conserved non-coding small RNAs during the process of biological evolution, and they regulate the expression of genes posttranscriptionally. Differential expression of miRNAs is involved in the physiological and pathological processes of many kinds of diseases. Evidence has shown that POPs can cause miRNAs express in disorder, resulting in the differential gene expression. Mounting evidence has suggested that miRNAs play very important roles in atherosclerosis. Consequently, POPs could be able to induce through the potential regulation of miRNAs.
点击查看大图
下载:
