全氟辛烷磺酸神经发育毒性机制研究进展

刘晓晖; 胡宏; 李双月; 邵静; 刘薇; 金一和

doi:10.7524/AJE.1673-5897.20130407001

全氟辛烷磺酸神经发育毒性机制研究进展

1. 大连医科大学公共卫生学院劳动卫生与环境卫生教研室, 大连 116044;

2. 大连医科大学附属二院检验科, 大连 116027;

3. 大连理工大学环境学院工业生态与环境工程教育部重点实验室, 大连 116024

作者简介: 刘晓晖(1981-),女,博士,研究方向为毒理学,E-mail:liuxh892@126.com

基金项目:

国家自然基金(81273031)

大连医科大学引进人才科研启动基金(201069)

大连理工大学工业生态与环境工程教育部重点实验室开放基金(KLIEEE-12-04)

中图分类号: X171.5

Research Progress on Mechanisms in the Developmental Neurotoxicity of PFOS

1. Department of Environmental Health and Toxicology, School of Public Health, Dalian Medical University, Dalian 116044, China;

2. Biochemistry Lab, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China;

3. Key Laboratory of Industrial Ecology and Environmental Engineering of Ministry of Education, School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China

Fund Project:

摘要: 全氟辛烷磺酸(PFOS)是全氟化合物的终端降解产物,在生态环境中能够通过食物链进入生物组织并蓄积,对环境和生物存在潜在危害。动物实验研究发现,PFOS能够通过胎盘和血脑屏障,影响发育期神经系统,其持续性和严重性已引起国内外学者的广泛关注。本文通过对PFOS神经发育毒性效应及其主要机制研究进展进行综述,分析目前研究现状,并对未来PFOS神经发育毒性机制研究提出设想和展望。

Abstract: Perfluorooctane sulfonates (PFOS), the terminal degradation products of perfluorinated compounds, can bioaccumulate through food chains and is regarded as a potential threat to our living environment. Studies in animals have shown that PFOS passes through placental barrier and blood brain barrier, and induces toxic effects in central nervous system (CNS). In particular, PFOS induces developmental neurotoxicity, and its severity and persistency have been widely recognized. In this current article, we thoroughly reviewed the developmental neurotoxicity by in vivo and in vitro exposure to PFOS and its underlying mechanisms. Furthermore, we discussed present problems in this area and put forward suggestions on future research.

Key words:

全氟辛烷磺酸神经发育毒性机制研究进展

作者简介: 刘晓晖(1981-),女,博士,研究方向为毒理学,E-mail:liuxh892@126.com
1. 大连医科大学公共卫生学院劳动卫生与环境卫生教研室, 大连 116044;

2. 大连医科大学附属二院检验科, 大连 116027;

3. 大连理工大学环境学院工业生态与环境工程教育部重点实验室, 大连 116024

收稿日期: 2013-04-07

基金项目:

国家自然基金(81273031)

大连医科大学引进人才科研启动基金(201069)

大连理工大学工业生态与环境工程教育部重点实验室开放基金(KLIEEE-12-04)

关键词:

Research Progress on Mechanisms in the Developmental Neurotoxicity of PFOS

1. Department of Environmental Health and Toxicology, School of Public Health, Dalian Medical University, Dalian 116044, China;

2. Biochemistry Lab, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China;

3. Key Laboratory of Industrial Ecology and Environmental Engineering of Ministry of Education, School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China

Received Date: 2013-04-07

Fund Project:

Keywords:

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